Optical coherence tomography (OCT) is a recently developed imaging technologythat has stimulated considerable interest in the fields of medicine, biology, andmaterial science. The unique capability of OCT to noninvasively explore microstructurewithin turbid media using nonionizing radiation has opened the door to applicationssuch as optical biopsy, surgical guidance, studies of developmental biology,and quality control of advanced composites in situ.
The technological innovations that have led to the current success of OCT aremanifold and have been published in the scientific literature of optical communications,optical engineering, applied physics, and biomedical engineering. Similarly, theapplications of OCT have been separately described in the publications of the relevantfields. The diversity of these publications has led to a need for a comprehensivehandbook describing OCT and detailing the advances. The aim of this book, then, isto address this need and to serve as a repository for engineers and scientists involvedwith the development of OCT technology. Sufficient detail is given to enable newcomersto the field to construct a state-of-the-art OCT imaging system. In addition,the book will serve as a reference for medical clinicians wishing to understand thefundamentals of OCT and its capabilities and limitations.
Chapter 1 presents historical background describing the development of OCTand includes citations to the primary literature. The following five chapters provide asummary of the technology specific to each of the major subcomponents of a typicalOCT system, including optical sources, fiber optics, temporal delay scanning, OCTprobe design, detection, and system integration. Chapters 7 through 13 are devotedto new imaging concepts spawned from OCT research, such as the reduction ofspeckle in OCT images, polarization-sensitive OCT, the detection of Doppler-shiftedbackreflection to determine flow, the combined use of OCT and confocal microscopy,spectral radar, and alternative imaging geometries for OCT.
The applications section (Chapters 14 to 28) begins with a summary of the useof OCT for measuring optical properties and a discussion of nonbiological applicationsof OCT such as monitoring advanced composites and optical data storage.Biological and medical applications are grouped by topic, beginning with developmentalbiology and continuing through the major human tissue systems that have been investigated. While the development of OCT has enjoyed widespread interest and has been pursued by many research groups throughout the world, the technology is still young. We hope the readers of this book will be motivated to explore new directions for this promising imaging modality.
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